Sodium Hydroxide → HCID 9859660, compound

Participants

Reaction Steps

Sodium cyanoborohydride (6.37 g) was added portionwise to a solution of 7.00 g 2-(2-amino-5-chlorophenyl)-1H-indole in 245 ml HOAc at 15° C. The resulting solution was stirred at room temperature for one day. The reaction mixture was diluted and made basic by addition of 50% NaOH in ice. The mixture was extracted with Et2O, and the extracts were washed with water and saturated NaCl solution, and dried (MgSO4). Concentration gave 6.48 g gum which was chromatographed by HPLC using CH2Cl2 /hexane (7:3) as eluent to give 2.56 g solid, m.p. 107°-109° C.

Provenance & Evidence