Sodium Hydroxide → HCID 19761429, compound

Participants

Reaction Steps

To a solution of 1.8 g 2-(2-amino-5-methoxyphenyl)-1H-indole in 60 ml acetic acid at 15° was added 1.8 g NaCNBH3 and this mixture was stirred at room temperature overnight and thereafter poured into excess 50% NaOH in ice. Extraction with CH2Cl2, drying (MgSO4), concentration and flash chromatography using 1% EtOAc/CH2Cl2 as an eluent gave 0.23 g solid, m.p. 120°-123° C.

Provenance & Evidence