Sodium Hydroxide → HCID 19761428, compound

Participants

Reaction Steps

Sodium cyanoborohydride (4.72 g) was added portionwise to a solution of 5.36 g 2-(2-methylamino-5-chlorophenyl)-1H-indole in 160 ml HOAc at 10° C. The mixture was stirred twenty hours at room temperature. It was then diluted and added to excess 50% NaOH in ice. The mixture was extracted with CH2Cl2, and the extracts were washed with saturated NaCl solution and dried (MgSO4). Concentration yielded 5.31 g solid. Purification by HPLC using CH2Cl2 /hexane (1:1) as eluent yielded 2.65 g solid, m.p. 106°-108° C.

Provenance & Evidence