Triethylamine → HCID 19761400, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5.00 g 2-(2-amino-5-chlorophenyl)-2,3-dihydro-1H-indole in 70 ml CH2Cl2 at 10° C. were added 3.14 ml triethylamine and then dropwise 2.52 ml trimethylacetylchloride. The resulting solution was stirred for one hour at 10° C. and then quenched with water. The organic phase was separated, washed with 7.5% NaHCO3 and saturated NaCl, dried (MgSO4), and concentrated to yield 5.67 g solid. Recrystallization from cyclohexane yielded 3.09 g solid, m.p. 195°-198° C.

Provenance & Evidence