Acetic Anhydride → HCID 19761440, compound

Participants

Reaction Steps

To a solution of 3.38 g 2,2-dimethyl-N-[2-(2,3-dihydro-1H-indol-2-yl)-4-chlorophenyl]propanamide in 40 ml CH2Cl2 at 10° C. were added 12.7 ml Et3N and then dropwise 6.59 ml acetic anhydride. The resulting mixture was stirred twenty-four hours at room temperature. The reaction was quenched with water (30 ml). The organic phase was separated, washed with 5% HCl, water, 7.5% NaHCO3 and sat. NaCl (1×), and dried (MgSO4). Concentration, trituration with hexane and recrystallization from cyclohexane gave 2.10 g solid, m.p. 131°-134° C.

Provenance & Evidence