HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl chloride → Propionate ion
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl chloride | HCID 7412 | — |
| Reactant | Propionic anhydride | HCID 31263 | — |
| Reactant | HCID 9861812 | HCID 9861812 | — |
| Product | Propionate ion | HCID 104745 | — |
| Product | (8R,9S,10R,13S,14R)-14-hydroxy-10,13-dimethyl-2,7,8,9,11,12,15,16-octahydro-1H-cyclopenta[a]phenanthrene-3,6,17-trione | HCID 6918079 | — |
Reaction Steps
The above compounds can be synthesized by the methods described in Japanese Patent Application Laid-Open Nos. 192794/1988 and 131193/1989. That is, 14α-hydroxy-4-androstene-3,6,17-trione is synthesized from 6β,14α-dihydroxy-4-androstene-3,17-dione according to an ordinary oxidation reaction (for example, Jones' oxidation reaction) and then is reacted with propionic anhydride or benzoyl chloride to obtain a propionate or a benzoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05166200 |
| Source dataset | uspto-grants-1992_11 |
| ORD ID | ord-63479b2df51e488eb4898015334d8643 |
| Source note | uspto-grants-1992_11 |