反应详情

Under reflux, for 20 minutes is heated a solution of 1.28 g (3.96 mmoles) of 1-(4-aminobutyl)-4-diphenylmethylpiperazine and 0.77 g (5.8 mmoles) of 2.5-dimethoxytetrahydrofurane in 25 ml of acetic acid. It is cooled, it is poured over ice water, neutralized with NaCHO3 and extracted with chloroform. It is dried with Na2SO4, and evaporated under vacuum to dryness. 1.7 g of crude oil is obtained which is purified on a silica chromatographic column (eluant: ethyl acetate). 0.95 g of 1-[4-(4-Diphenylmethyl-1-piperazinyl)butyl]pyrrole is obtained in solid form, with a melting point 80°-84° C.

1. temperatureUnder reflux, for 20 minutes
2. temperatureIt is cooled
3. extractionextracted with chloroform
4. dry with materialIt is dried with Na2SO4
5. customevaporated under vacuum to dryness
6. custom1.7 g of crude oil is obtained which
7. customis purified on a silica chromatographic column (eluant: ethyl acetate)