Sodium Iodide → HCID 14986606, compound

Participants

Reaction Steps

Under reflux for 4 hours is placed a mixture of 6.3 g (25 mmoles) of diphenylmethyl piperazine, 6.87 g (25 mmoles) of 1-(4-bromobutyl)-4-ethyloxycarbonylpyrazole, 5.17 g (37.5 moles) of potassium carbonate and 5.06 g (33.7 mmoles) of sodium iodide in 100 ml of methyl ethyl ketone. It is cooled, filtered and the filtrate evaporated to dryness. The residue is taken up again with chloroform and water, the organic phase is dried with Na2SO4, it is filtered and evaporated under vacuum. The resulting product is purified on a chromatographic silica column (eluant: chloroform-methanol 95:5) and in this way 7.4 g of 1-[4-(4-Diphenylmethyl-1-piperazinyl)butyl]-4-ethyloxycarbonylpyrazole is obtained, with a melting point 70°-74° C.

Provenance & Evidence