Bromotrimethylsilane → HCID 3009294, compound

Participants

Reaction Conditions

Reaction Steps

2,6-Diamino-9-[4-(diethoxyphosphoryl)butoxy]purine (0.07 g, 0.2 mmol) and bromotrimethylsilane (0.26 ml, 2 mmol) were dissolved in dimethylformamide (3 ml) and the reaction mixture was stirred at 23° C. for 4 hr. The solvent was evaporated under vacuum and the residue dissolved in methanol-water solution (8:2). The material crystallised from the solution to give the title compound as colourless crystals (0.05 g, 84%), m.p. 295°-297° C. 1H NMR: δH [(CD3)2SO+D2O] 1.68 (6H, m, CH2CH2CH2P), 4.31 (2H, t, J=6 Hz, NOCH2), 8.35 (1H, s, H-8).

Provenance & Evidence