Bromotrimethylsilane → HCID 461343, compound

Participants

Reaction Conditions

Reaction Steps

9-[4-(Diethoxyphosphoryl)butoxy]adenine (0.165 g, 0.48 mmol) and bromotrimethylsilane (0.62 ml, 4.8 mmol) were dissolved in dimethylformamide (5 ml) and the reaction mixture was stirred at 23° C. for 90 min. The solvent was evaporated and the residue dissolved in methanol-water solution (9:1). The material crystallised from the solution to give the title compound as colourless crystals (96 mg, 70%), m.p. 265°-268° C. 1H NMR: δH [CD3)2SO] 1.77 (6H, m, CH2CH2CH2P), 4.45 (2H, t, J=6 Hz, NOCH2), 7.46 (2H, br.s., D2O exchangeable, NH2), 8.24 (1H, s), 8.48 (1H, s).

Provenance & Evidence