6-Methylamino-9-((2R,3R,4S)-3,4-bis(hydroxymethyl)-oxetan-2-yl)purine → 6-Methylamino-9-((2R,3R,4S)-4-hydroxymethyl-3-methyl-oxetan-2-yl)purine

HRID 37393Notes

Reaction equation

HRID 37393 reaction equation
[CH3:1][NH:2][C:3]1[N:11]=[CH:10][N:9]=[C:8]2[C:4]=1[N:5]=[CH:6][N:7]2[C@H:12]1[C@H:15]([CH2:16]O)[C@@H:14]([CH2:18][OH:19])[O:13]1.OC[C@H]1O[C@@H](N2C=NC3C2=NC=NC=3N)[C@@H]1C>>[CH3:1][NH:2][C:3]1[N:11]=[CH:10][N:9]=[C:8]2[C:4]=1[N:5]=[CH:6][N:7]2[C@H:12]1[C@H:15]([CH3:16])[C@@H:14]([CH2:18][OH:19])[O:13]1

Participants

3

Reactant 2

HCID 677173796-Methylamino-9-((2R,3R,4S)-3,4-bis(hydroxymethyl)-oxetan-2-yl)purineHCID 677177159-((2R,3R,4S)-4-Hydroxymethyl-3-methyl-oxetan-2-yl) adenine

Product 1

HCID 677173886-Methylamino-9-((2R,3R,4S)-4-hydroxymethyl-3-methyl-oxetan-2-yl)purine

Procedure

The procedure of Example 9 can be repeated replacing the starting compound of Example 9 (a) with the product of Example 1 to obtain the desired compound.

Sources & evidence

ORD record
ord-eb63652c357e4cc4a8c833b8d6804712
Source dataset
uspto-grants-1995_05
Patent number
US05420276

Reaction notes

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