HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Sulfamoylbenzaldehyde → 4-(2-Cyanoethyl)benzene-1-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Sulfamoylbenzaldehyde | HCID 151088 | — |
| Reactant | Diethyl cyanomethylphosphonate sodium hydride | HCID 86740749 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(2-Cyanoethyl)benzene-1-sulfonamide | HCID 19809182 | — |
Reaction Steps
For the preparation of the amine starting material of Example 24, p-aminosulfonylbenzaldehyde was reacted with diethyl cyanomethylphosphonate/sodium hydride in tetrahydrofuran to give 1-cyano-2-(4-aminosulfonylphenyl)-ethane which was hydrogenated in methanol with Raney-cobalt as the catalyst to give 3-(4-aminosulfonylphenyl)-propylamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05166218 |
| Source dataset | uspto-grants-1992_11 |
| ORD ID | ord-8bc65334e40b4b40a9a33b15d5f52267 |
| Source note | uspto-grants-1992_11 |