2,4-Difluorophenyl isocyanate → HCID 10339996, compound

Participants

Reaction Conditions

Reaction Steps

Part C. A solution of the amine prepared in Part C (4.26 g, 18.6 mmol) in methylene chloride (20 mL) was cooled to 0° C., and a solution of 2,4-difluorophenyl isocyanate (2.20 mL, 18.6 mmol) in methylene chloride (20 mL) was added dropwise with stirring over 1 hour. After slow warming to ambient temperature over 18 hours, the reaction mixture was concentrated under vacuum, and the residual oil was purified by flash chromatography to afford N'-(2,4-difluorophenyl)-N-(3,3-dimethyl-5-hydroxypentyl)-N-heptylurea as a colorless oil (2.31 g, 6.01 mmol, 32%). 1H NMR (CDCl3) δ7.93(br q,1H,J=6.2Hz); 6.89-6.78(m,3H); 3.76(t,2H,J=6.3Hz); 3.38-3.24(m,4H); 2.36(br s,1H); 1.65-1.52(m,6H); 1.36-1.24(m,8H); 0.97(s,6H); 0.89(t,3H,J=6.6Hz).

Provenance & Evidence