Methyl iodide → HCID 19809374, compound

Participants

Reaction Steps

To a stirred suspension of 5 g (0.023 mole) of 4-chloro-6,7-dihydro-2-ethyl-5H-pyrimido[4,5-b][1,4]oxazin-6-one (prepared using the method of Melik-Ogandzhanyan, et al., Khimiya Geterotsiklicheskikh Soedinenii, 1985, 974) in 100 ml of N,N-dimethylformamide was added 0.75 g (0.025 mole) of 80% sodium hydride in oil. After ten minutes 3.5 g (0.025 mole) of methyl iodide was added. After two hours the solution was diluted with about 400 ml of water, and extracted thrice with 250 ml portions of chloroform. The extracts were washed with water, dried over magnesium sulfate, treated with decolorizing charcoal, and evaporated in vacuo. The resulting oil was triturated with a mixture of diethyl ether and hexanes to provide light green solid 4-chloro-6,7-dihydro-2-ethyl-5-methylpyrimido[4,5-b][1,4]oxazin-6-one.

Provenance & Evidence