Potassium Carbonate → 2-Ethyl-1-(2-nitro-5-fluorophenyl)-4-methyl-1H-imidazole

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Reaction Steps

Combine 100 g of 2,4-difluoronitrobenzene, 69 g of 2-ethyl-4-methylimidazole and 100 g of K2CO3 in 700 mL of acetonitrile, and stir at room temperature for 4 days. Remove the solvent under vacuum. Slurry the residue in 300 mL of CH2Cl2 and chromatograph over 1 kg of silica gel using CH2Cl2. Combine the appropriate fractions and remove the solvent under vacuum. Crystallize the residue from pet ether to provide the title compound.

Provenance & Evidence