Hydrogen Peroxide → HCID 11789721, compound

Participants

Reaction Conditions

Reaction Steps

3.2 g (0.02 mol) of 3-amino-4-methoxycarbonyl-2,5-dihydrothiophene are suspended in 30 ml of isopropanol. 2.2 ml of 35% strength hydrogen peroxide are added, with cooling. The mixture is then stirred at an internal temperature of 50° C. until starting material can no longer be detected in a thin layer chromatogram (approx. 5 hours). The mixture is then cooled in an ice bath and the precipitated crystals are filtered off with suction and washed with ice-cold isopropanol and with diethyl ether. Yield: 3.5 g (91% of theory). When recrystallized from methanol, the crystals melt at 137°-140° C.

Provenance & Evidence