HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 6-benzensulfonylamino-1-benzyl-4-methylhexahydro-1H-1,4-diazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Aziridine, 2-(bromomethyl)-1-(phenylsulfonyl)- | HCID 243646 | — |
| Reactant | N~1~-Benzyl-N~2~-methylethane-1,2-diamine | HCID 10920861 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 6-benzensulfonylamino-1-benzyl-4-methylhexahydro-1H-1,4-diazepine | HCID 10067037 | 22.3% |
Reaction Steps
A mixture of 1-benzenesulfonyl-2-bromomethylethylenimine (27.2 g), N-benzyl-N'-methylethylenediamine (16.2 g), triethylamine (19.9 g) and chloroform (350 ml) is refluxed with stirring for 5 hours. The solvent is evaporated under reduced pressure, and the residue is purified by silica gel chromatography to give the title compound (7.9 g) as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05166341 |
| Source dataset | uspto-grants-1992_11 |
| ORD ID | ord-57966f3d65c846eb9165fb83d19ec86a |
| Source note | uspto-grants-1992_11 |