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HRID374125

反应详情

EQUATION

反应方程式

HRID 374125 的结构方程式

REACTANTS

反应物

2
结构：CC1(C)NC(=O)NC1=O
HCID6491

5,5-Dimethylhydantoin

C5H8N2O2

结构：O=[N+]([O-])c1ccc(Cl)cc1C(F)(F)F
HCID67052

5-Chloro-alpha,alpha,alpha-trifluoro-2-nitrotoluene

C7H3ClF3NO2

PRODUCTS

生成物

1
结构：CC1(C)NC(=O)N(c2ccc([N+](=O)[O-])c(C(F)(F)F)c2)C1=O
HCID4493

Nilutamide

C12H10F3N3O4

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Cu]
催化剂HCID23978

Copper

Cu

结构：CCO
溶剂HCID702

Ethanol

C2H6O

2 次

CONDITIONS

反应条件

温度
200 °C

PROCEDURE

实验过程

71.5 grams of copper in powder form were added to 96.10 grams of 5,5-dimethyl-hydantoin and 170.86 grams of 2-nitro-5-chloro trifluoromethylbenzene. The mixture was heated to 200° C. for about 21 hours, the pressure being maintained at 450 millibars, then, was cooled to 20° C. and taken up in 480 ml of ethanol. The product was characterized and determined by thin layer chromatography of the ethanol solution.

WORKUP

后处理

  1. temperaturethe pressure being maintained at 450 millibars
  2. temperaturewas cooled to 20° C.