Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylhydantoin | HCID 6491 | — |
| Reactant | Diphenyl Ether | HCID 7583 | — |
| Reactant | 5-Chloro-2-nitrobenzotrifluoride | HCID 67052 | — |
| Product | Nilutamide | HCID 4493 | — |
Reaction Steps
The following were introduced into 288 ml of phenyl oxide: 96.10 grams of 5,5-dimethyl-hydantoin, 170.86 grams of 2-nitro-5-chloro trifluoromethylbenzene and 89.40 grams of cupric oxide. The mixture was heated to 190° C. for about 23 hours, then cooled to 20° C. and filtered. The residue was characterized in the phenyl oxide filtrate by thin layer chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05166358 |
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| Source dataset | uspto-grants-1992_11 |
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| ORD ID | ord-250000bbc78844a9a114c6ed9b1ccd4b |
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| Source note | uspto-grants-1992_11 |
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