3,3-Dimethylbutylamine → HCID 19734483, compound

HRID 374146Notes

Reaction equation

HRID 374146 reaction equation
[C:1]([N:3]=[C:4]([C:9]1[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=1)OC(C)C)#[N:2].[CH3:15][C:16]([CH3:21])([CH3:20])[CH2:17][CH2:18][NH2:19]>CO>[C:1]([NH:3][C:4]([C:9]1[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=1)=[N:19][CH2:18][CH2:17][C:16]([CH3:21])([CH3:20])[CH3:15])#[N:2]

Participants

4

Reactant 2

HCID 197093,3-DimethylbutylamineHCID 100812013-Pyridinecarboximidic acid, N-cyano-, 1-methylethyl ester

Product 1

HCID 19734483HCID 19734483, compoundYield 63%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Isopropyl N-cyano-3-pyridinecarboximidate (0.60 g, 3.2 mmol) was dissolved in methanol (10 ml), and 3,3-dimethylbutylamine (0.36 g, 3.6 mmol) was added. The mixture was stirred at room temperature for 20 minutes. After the reaction was completed, the reaction solution was concentrated under reduced pressure, and the concentrated residue was crystallized from dichloromethane-diethyl ether to give the title compound (0.46 g, 2.0 mmol, yield: 63%) as colorless needles.

Workup

  1. concentrationthe reaction solution was concentrated under reduced pressure
  2. customthe concentrated residue was crystallized from dichloromethane-diethyl ether

Sources & evidence

ORD record
ord-15b2c58ed6ec466a96b18c5d1cf94ece
Source dataset
uspto-grants-1992_11
Patent number
US05166347

Reaction notes

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