3,5-Bis(trifluoromethyl)benzylamine → HCID 19734549, compound

HRID 374156Notes

Reaction equation

HRID 374156 reaction equation
[C:1]([N:3]=[C:4]([C:9]1[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=1)OC(C)C)#[N:2].[F:15][C:16]([F:30])([F:29])[C:17]1[CH:18]=[C:19]([CH:22]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:24]=1)[CH2:20][NH2:21]>CO>[C:1]([NH:3][C:4]([C:9]1[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=1)=[N:21][CH2:20][C:19]1[CH:22]=[C:23]([C:25]([F:26])([F:27])[F:28])[CH:24]=[C:17]([C:16]([F:15])([F:29])[F:30])[CH:18]=1)#[N:2]

Participants

4

Reactant 2

HCID 5210993,5-Bis(trifluoromethyl)benzylamineHCID 100812013-Pyridinecarboximidic acid, N-cyano-, 1-methylethyl ester

Product 1

HCID 19734549HCID 19734549, compoundYield 35%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Isopropyl N-cyano-3-pyridinecarboximidate (0.50 g, 2.6 mmol) was dissolved in methanol (10 ml), and 3,5-bis(trifluoromethyl)benzylamine (0.71 g, 2.9 mmol) was added. The mixture was stirred at room temperature for 1 hour. After the reaction was completed, the reaction solution was concentrated under reduced pressure, and the concentrated residue thus obtained was crystallized from diethyl ether to give the title compound (0.34 g, 0.91 mmol, yield: 35%) as colorless crystals.

Workup

  1. concentrationthe reaction solution was concentrated under reduced pressure
  2. customthe concentrated residue thus obtained
  3. customwas crystallized from diethyl ether

Sources & evidence

ORD record
ord-4caa0cafb97f4e16bb0e420446091c86
Source dataset
uspto-grants-1992_11
Patent number
US05166347

Reaction notes

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