2-(4-Aminophenyl)ethylamine → HCID 19809436, compound

HRID 374162Notes

Reaction equation

HRID 374162 reaction equation
C(N=[C:4]([C:9]1C=NC=CC=1)[O:5][CH:6](C)[CH3:7])#[N:2].[NH2:15][C:16]1C=C[C:19]([CH2:22][CH2:23][NH2:24])=[CH:18][CH:17]=1>CO>[CH3:4][OH:5].[N:24]1[CH:23]=[CH:22][CH:19]=[CH:18][C:17]=1[C:16](=[NH:2])[NH2:15].[CH2:4]([O:5][CH2:6][CH3:7])[CH3:9]

Participants

4

Reactant 2

HCID 728952-(4-Aminophenyl)ethylamineHCID 100812013-Pyridinecarboximidic acid, N-cyano-, 1-methylethyl ester

Product 1

HCID 19809436HCID 19809436, compoundYield 124.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Isopropyl N-cyano-3-pyridinecarboximidate (1.0 g, 5.3 mmol) was dissolved in methanol (15 ml), and 2-(4-aminophenyl)ethylamine (0.80 g, 5.8 mmol) was added. The mixture was stirred at room temperature for 1 hour. After the reaction was completed, the reaction solution was concentrated under reduced pressure. The residual concentrate was crystallized from methanol-diethyl ether pyridinecarboximidamide (0.88 g, 3.3 mmol, yield: 63%) as colorless needles.

Workup

  1. concentrationthe reaction solution was concentrated under reduced pressure
  2. concentrationThe residual concentrate

Sources & evidence

ORD record
ord-47d79317f96d47a6aeebbd374e1ade7e
Source dataset
uspto-grants-1992_11
Patent number
US05166347

Reaction notes

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