2-(4-Chlorophenyl)ethylamine → HCID 19734508, compound

HRID 374177Notes

Reaction equation

HRID 374177 reaction equation
[C:1]([N:3]=[C:4]([C:9]1[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=1)OC(C)C)#[N:2].[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][NH2:24])=[CH:18][CH:17]=1>CO>[C:1]([NH:3][C:4]([C:9]1[CH:10]=[CH:11][N:12]=[CH:13][CH:14]=1)=[N:24][CH2:23][CH2:22][C:19]1[CH:20]=[CH:21][C:16]([Cl:15])=[CH:17][CH:18]=1)#[N:2]

Participants

4

Reactant 2

HCID 674302-(4-Chlorophenyl)ethylamineHCID 10012715Isopropyl N-cyano-4-pyridinecarboximidate

Product 1

HCID 19734508HCID 19734508, compoundYield 58%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

Isopropyl N-cyano-4-pyridinecarboximidate (0.5 g, 2.6 mmol) was dissolved in methanol (5 ml), and 2-(4 chlorophenyl)ethylamine (0.46 g, 3.0 mmol) having been diluted with methanol (5 ml) was added. The mixture was stirred at room temperature for 40 minutes. After the reaction was completed, the reaction solution was then concentrated under reduced pressure. The residual concentrate was further crystallized from methanol-diethyl ether to give the title compound (0.44 g, 1.5 mmol, yield: 58%) as colorless needles.

Workup

  1. additionwas added
  2. concentrationthe reaction solution was then concentrated under reduced pressure
  3. concentrationThe residual concentrate
  4. customwas further crystallized from methanol-diethyl ether

Sources & evidence

ORD record
ord-efcdbda8376d42419dbb02084be1cce1
Source dataset
uspto-grants-1992_11
Patent number
US05166347

Reaction notes

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