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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 374184Generated: October 26, 2026

Phenethylamine → N-cyano-N'-(2-phenylethyl)-3-quinolinecarboximidamide

https://huagongshe.com/reaction/374184

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhenethylamineHCID 1001—
ReactantMethyl N-cyano-3-quinolinecarboximidateHCID 10058988—
SolventMethanolHCID 887—
ProductN-cyano-N'-(2-phenylethyl)-3-quinolinecarboximidamideHCID 1973457891%

Reaction Steps

Methyl N-cyano-3-quinolinecarboximidate (0.32 g, 1.5 mmol) was dissolved in methanol (3 ml), 2-phenylethylamine (0.20 g, 1.65 mmol) was added. The mixture was stirred at room temperature for 30 minutes. After the reaction was completed, the reaction solution was concentrated under reduced pressure, and the residue thus obtained was crystallized from diethyl ether to give the title compound (0.41 g, 1.36 mmol, yield: 91%) as pale yellow crystals.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05166347
Source datasetuspto-grants-1992_11
ORD IDord-8b1176c302094b4db4b577bbc91cafd4
Source noteuspto-grants-1992_11