Acetic Acid → HCID 19734528, compound

HRID 374190Notes

Reaction equation

HRID 374190 reaction equation
[C:1]([C:3]1[CH:7]=[CH:6][O:5][CH:4]=1)#[N:2].C[O-].[Na+].[C:11](O)(=[O:13])C>CO>[O:5]1[CH:6]=[CH:7][C:3]([C:1](=[NH:2])[O:13][CH3:11])=[CH:4]1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 1006983-Furancarbonitrile (9CI)HCID 10942334Sodium Methoxide

Product 1

HCID 19734528HCID 19734528, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3-cyanofuran (3.76 g, 40.1 mmol) was dissolved in methanol (30 ml), and sodium methoxide (0.1 g, 1.9 mmol) was added. The mixture was stirred at room temperature for 18 hours. After the reaction was completed, acetic acid (0.14 g, 2.3 mmol) was added to neutralize the reaction solution, and the solution was concentrated under reduced pressure. Diethyl ether was added to the concentrated residue, and insolubles were removed by filtration. The filtrate was concentrated under reduced pressure to give the crude product of methyl 3-furancarboximidate as a pale yellow oil.

Workup

  1. concentrationthe solution was concentrated under reduced pressure
  2. additionDiethyl ether was added to the concentrated residue, and insolubles
  3. customwere removed by filtration
  4. concentrationThe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-24998ff83cbf480ba7e6cfde8f5cef55
Source dataset
uspto-grants-1992_11
Patent number
US05166347

Reaction notes

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