Methyl Acrylate → Methyl 3‐[methoxy(methyl)phosphoryl]propanoate

Participants

Reaction Conditions

Reaction Steps

A mixture of 86 g of methyl acrylate and 80 g of ethanol is added dropwise in the course of 30 minutes at 60° C. under nitrogen to a solution of 108 g of dimethyl methanephosphonate. The reaction mixture is then stirred at 60° C. for one hour. A total of 55 g of methyl ethyl ether are collected in the cooling trap. Excess ethanol is then removed by vacuum distillation. The crude product is obtained in a yield of 184 g with a 95.4% purity, which corresponds to a theoretical yield of 97.5%.

Provenance & Evidence