HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenol → Methyl 3-(phenyl-methoxyphosphinyl)-2-chloropropionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | Methyl 2-chloroacrylate | HCID 6659 | — |
| Reactant | Phosphonic acid, phenyl-, dimethyl ester | HCID 75234 | — |
| Product | Methyl 3-(phenyl-methoxyphosphinyl)-2-chloropropionate | HCID 15052091 | 90.1% |
Reaction Steps
138 g of dimethyl phenylphosphonate are slowly added at 20° C. under nitrogen to a solution of 120.5 g of methyl 2-chloroacrylate and 94 g of phenol. After a reaction time of 3 hours at 70° C. phenetole is removed by vacuum distillation. The residue represents 267 g of crude product with a 93.0% purity, which corresponds to a theoretical yield of 90.1%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05166385 |
| Source dataset | uspto-grants-1992_11 |
| ORD ID | ord-3307f53977b44fc8a76ecf241fbf580d |
| Source note | uspto-grants-1992_11 |