Bromine → HCID 19809490, compound

Participants

Reaction Conditions

Reaction Steps

A solution of the hydrobromide salt of (±) 5-acetyl-1-azabicyclo[3.2.1]octane (D4) (2.0g; 8.5 mmole) in dry methanol (35ml) was cooled to -10° C. and treated with a solution of bromine (0.44ml; 8.5 mmole) in dry methanol (5ml). The reaction was maintained at 0° C. for 18h. A further quantity of bromine (0.44 ml) was added and after 5h at room temperature the reaction was diluted with water and stirred for 1h. Evaporation of solvent and excess reagent in vacuo afforded a yellow foam (3.0 g) consisting mainly of the title compound (D5). This material was used in the next stage without purification.

Provenance & Evidence