Thionyl Chloride → HCID 19809486, compound

Participants

Reaction Steps

A solution of (±)5-(2-hydroxymethyl-1,3-oxazol-5-yl)-1-azabicyclo[3.2.1]octane (E10) (0.3g, 1.4 mmol) in absolute chloroform (10 ml) under nitrogen, cooled in ice was treated with thionyl chloride (0.31 ml, 4.3 mmole) over 5 minutes. The reaction was allowed to warm up to room temperature over 45 minutes. Evaporation of solvent in vacuo afforded the title compound (D25) as a brown solid (380 mg, 100%) which was used without purification.

Provenance & Evidence