Acetic Anhydride → HCID 19809511, compound

Participants

Reaction Steps

A solution of (±)5-(2-amino-1,3-oxazol-5-yl)-1-azabicyclo[3.2.1]octane (E3) (0.25g, 1.3 mmole) in acetic anhydride (8 ml) was refluxed for 1h under nitrogen. The reaction mixture was concentrated in vacuo and the residue treated with saturated aqueous potassium carbonate solution (10 ml). After extraction into chloroform (3×10 ml) the organic extracts were dried over sodium sulphate and concentrated in vacuo. Trituration of the resulting gum with ether afforded the title compound (E14) as a solid (180 mg, 60%) m.p. 142°-143° C. (from methanol-ether).

Provenance & Evidence