HCID 86746387, compound → HCID 86746388, compound

HRID 374290Notes

Reaction equation

HRID 374290 reaction equation
[CH3:1][C:2]1[CH:18]=[C:17]([O:19]CC2C=CC=CC=2)[C:16]([CH3:27])=[CH:15][C:3]=1[O:4][CH2:5][CH2:6][CH2:7][C:8]([CH3:14])([CH3:13])[C:9]([O:11][CH3:12])=[O:10]>CO.[Pd]>[OH:19][C:17]1[C:16]([CH3:27])=[CH:15][C:3]([O:4][CH2:5][CH2:6][CH2:7][C:8]([CH3:13])([CH3:14])[C:9]([O:11][CH3:12])=[O:10])=[C:2]([CH3:1])[CH:18]=1

Participants

4

Reactant 1

HCID 86746387HCID 86746387, compound

Product 1

HCID 86746388HCID 86746388, compoundYield 107%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 1.85 g (5 mmol) of 5-[2,5-dimethyl-4-(phenylmethoxy)phenoxy]-2,2-dimethylpentanoic acid, methyl ester (Example 13) in 100 mL of methanol and 0.2 g of 20% palladium on carbon is shaken under a hydrogen atmosphere of 50 pounds per square inch (psi) for 14 hours. The catalyst is removed and the solvent is evaporated to afford the title compound as a colorless oil (1.5 g).

Workup

  1. customThe catalyst is removed
  2. customthe solvent is evaporated

Sources & evidence

ORD record
ord-fda88ff8d1ce46df93a666ad97625fb4
Source dataset
uspto-grants-1992_11
Patent number
US05166398

Reaction notes

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