HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → methyl 2-(3-acetylphenoxymethyl)phenylglyoxylate O-methyloxime
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 3-Hydroxyacetophenone | HCID 8487 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 2-[2-(bromomethyl)phenyl]-2-(methoxyimino)acetate | HCID 54028047 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | methyl 2-(3-acetylphenoxymethyl)phenylglyoxylate O-methyloxime | HCID 54262751 | 85% |
Reaction Steps
3.0 g (0.022 mol) of 3-hydroxyacetophenone and 6.0 g (0.021 mol) of methyl 2-bromomethylphenylglyoxylate O-methyloxime are dissolved in 30 ml of dimethylformamide, and 5.5 g (0.040 yol) of potassium carbonate are added. The mixture is stirred at room temperature for 24 hours, hydrolyzed with water and extracted with methyl tert-butyl ether. The organic phase is washed with water, dried and concentrated. 5.8 g (85%) of methyl 2-(3-acetylphenoxymethyl)phenylglyoxylate O-methyloxime are obtained as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05166399 |
| Source dataset | uspto-grants-1992_11 |
| ORD ID | ord-ef1a86baefb541b0b7066bb94a39a966 |
| Source note | uspto-grants-1992_11 |