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Water → methyl 2-(4-acetylphenoxymethyl)phenylglyoxylate O-methyloxime
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 4'-Hydroxyacetophenone | HCID 7469 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Methyl 2-[2-(bromomethyl)phenyl]-2-(methoxyimino)acetate | HCID 54028047 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | methyl 2-(4-acetylphenoxymethyl)phenylglyoxylate O-methyloxime | HCID 54461346 | 78% |
反応手順
3.0 g (0.022 mol) of 4-hydroxyacetophenone and 6.0 g (0.021 mol) of methyl 2-bromomethylphenylglyoxylate O-methyloxime are dissolved in 30 ml of dimethylformamide, and 5.5 g (0.040 mol) of potassium carbonate are added. The mixture is stirred at room temperature for 24 hours, hydrolyzed with water and extracted with methyl tert-butyl ether. The organic phase is washed with water, dried and concentrated. 5.3 g (78%) of methyl 2-(4-acetylphenoxymethyl)phenylglyoxylate O-methyloxime are obtained as a colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05166399 |
| 出典データセット | uspto-grants-1992_11 |
| ORD ID | ord-5013323b703d4b5e87fcb344ac0b1603 |
| 出典メモ | uspto-grants-1992_11 |