HCID 14997134, compound → HCID 14997135, compound

HRID 374318Notes

Reaction equation

HRID 374318 reaction equation
C([O:8][C:9]([C@@H:11]([CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)[CH2:12][C@H:13]([CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:14]([O:16][CH2:17][O:18][C:19](=[O:24])[C:20]([CH3:23])([CH3:22])[CH3:21])=[O:15])=[O:10])C1C=CC=CC=1>C(O)C.[Pd]>[C:19]([O:18][CH2:17][O:16][C:14]([C@@H:13]([CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[CH2:12][C@H:11]([CH2:32][C:33]1[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1)[C:9]([OH:10])=[O:8])=[O:15])(=[O:24])[C:20]([CH3:22])([CH3:23])[CH3:21]

Participants

4

Reactant 1

HCID 14997134HCID 14997134, compound

Product 1

HCID 14997135HCID 14997135, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 2.5 g of pivaloyloxymethyl 4-(benzyloxycarbonyl)-(R*,R*)-2,4-dibenzylbutyrate in 75 ml of ethanol is hydrogenated at atmospheric pressure in the presence of 0.2 g of 5% palladium on carbon. The reaction is filtered and evaporated to give 4-(pivaloyloxymethoxycarbonyl)-2,4-(R*,R*)-dibenzylbutyric acid.

Workup

  1. filtrationThe reaction is filtered
  2. customevaporated

Sources & evidence

ORD record
ord-27edc97e397747feae68200b3373905f
Source dataset
uspto-grants-1992_11
Patent number
US05166212

Reaction notes

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