反应详情

温度

0 °C

A mixture of 29 g of the 2-mercaptophenylsulfonamide triethylamine salt obtained in accordance with Example H6 and 2 g of 2-bromo-1-fluoroethane in 130 ml of tetrahydrofuran is stirred for 6 hours at a temperature of +40° C. to +45° C. The reaction mixture is then cooled to 0° C. and filtered. The filtrate is evaporated and the resulting residue is crystallized from methylene dichloride to give 21.2 g (90.2% of theory) of 2-(2-fluoroethylthio)-phenylsulfonamide having a melting point of +84° to +85° C.

1. filtrationfiltered
2. customThe filtrate is evaporated
3. customthe resulting residue is crystallized from methylene dichloride