反应详情

A mixture of 2 g 1,3-bis[[3-(p-acetoxyphenyl)-1-cycloheptylureido]methyl]benzene (compound of Example 42), 30 ml ethanol and 30 ml of 5% aqueous sodium carbonate solution was heated under reflux for ten minutes. After distilling off the ethanol under reduced pressure, water was added to the residue, and the resulting mixture was acidified by addition of concentrated hydrochloric acid under ice cooling. The solid which separated out was collected by filtration and recrystallized from methanol, giving 1 g of 1,3-bis[[1-cycloheptyl-3-(p-hydroxyphenyl)ureido]methyl]benzene.

1. temperaturewas heated
2. temperatureunder reflux for ten minutes
3. distillationAfter distilling off the ethanol under reduced pressure, water
4. additionwas added to the residue
5. additionthe resulting mixture was acidified by addition of concentrated hydrochloric acid under ice cooling
6. customThe solid which separated out
7. filtrationwas collected by filtration
8. customrecrystallized from methanol