Hydroxyamine hydrochloride → HCID 18996941, compound

Participants

Reaction Steps

A mixture of hydroxylamine hydrochloride (0.4 g) and 3-cyclopropyl-1-(3,5-dichloropyridin-2-yl)-2-(dimethyl amino)methylenepropan-1,3-dione (1.68 g) in ethanol was stirred at room temperature overnight. The solvent was removed by evaporation and the residue was dissolved in dichloromethane. The resulting solution was washed with water, dried (anhydrous magnesium sulphate), filtered and evaporated. The residue was purified by column chromatography on silica eluted with a mixture of ethyl acetate and hexane to yield 5-cyclopropyl-4-(3,5-dichloropyridin-2-oyl)isoxazole (compound 1, 0.38 g) as a white solid, m.p. 81.9°-83.1° C.

Provenance & Evidence