Hydrochloric Acid → HCID 18996929, compound

Participants

Reaction Conditions

Reaction Steps

Methyl cyclopropyl ketone (1.65 g) was added to a stirred suspension of sodium hydride (80% dispersion in oil; 0.6 g) in dry diethyl ether at 0° C. under an inert atmosphere. The mixture was stirred at 0° C. for one hour. Ethyl 3,5-dichloropyridine-2-carboxylate (2.16 g) was added and the mixture was stirred at 0° C. for 1 hour and then at room temperature overnight. Hydrochloric acid (2N) was added and the mixture was extracted with diethyl ether. The organic extracts were washed with water, dried (anthydrous magnesium sulphate), filtered and evaporated to give a brown gum which was purified by column chromatography on silica eluted with a mixture of ethyl acetate and hexane to yield 3-cyclopropyl-1-(3,5-dichloropyridin-2-yl)propan1,3-dione (1.35 g) as a colourless solid, m.p. 50.2°-52.7° C.

Provenance & Evidence