HRID37442

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14797

Potassium hydroxide

HKO

$结构：COC(=O)c1ccc(/C=C(\C)c2ccc3c(c2)N(C)CCN3C)cc1$

HCID67783456

未命名化合物

PRODUCTS

生成物

$结构：C/C(=C\c1ccc(C(=O)O)cc1)c1ccc2c(c1)N(C)CCN2C$

HCID67591124

未命名化合物

收率 78.3%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

600 mg of this ester were converted into the free acid by reaction with a solution of 1.5 g of potassium hydroxide in 25 ml of ethanol and 10 ml of water at 50° C. during 4 hours. After recrystallization from ethyl acetate/hexane, there were obtained 450 mg of p-[(E)-2-(1,2,3,4-tetrahydro-1,4-dimethyl-6-quinoxalinyl)propenyl]benzoic acid in the form of orange crystals, melting point 203°-205° C.

WORKUP

后处理

customAfter recrystallization from ethyl acetate/hexane