1-Methylbenzo[e]benzimidazol-2-amine → diethyl 4-[N-(1-methyl-1H-naphtho[1,2-d]-imidazol-2-yl)carbamoyl]benzylphosphonate

HRID 374423Notes

Reaction equation

HRID 374423 reaction equation
[NH2:1][C:2]1[N:6]([CH3:7])[C:5]2[C:8]3[C:13]([CH:14]=[CH:15][C:4]=2[N:3]=1)=[CH:12][CH:11]=[CH:10][CH:9]=3.[CH2:16]([O:18][P:19]([CH2:24][C:25]1[CH:33]=[CH:32][C:28]([C:29](Cl)=[O:30])=[CH:27][CH:26]=1)([O:21][CH2:22][CH3:23])=[O:20])[CH3:17]>>[CH3:7][N:6]1[C:5]2[C:8]3[C:13]([CH:14]=[CH:15][C:4]=2[N:3]=[C:2]1[NH:1][C:29]([C:28]1[CH:32]=[CH:33][C:25]([CH2:24][P:19](=[O:20])([O:18][CH2:16][CH3:17])[O:21][CH2:22][CH3:23])=[CH:26][CH:27]=1)=[O:30])=[CH:12][CH:11]=[CH:10][CH:9]=3

Participants

3

Reactant 2

HCID 1491151-Methylbenzo[e]benzimidazol-2-amineHCID 104469734-[(Diethoxyphosphoryl)-methyl]benzoyl chloride

Product 1

HCID 18997026diethyl 4-[N-(1-methyl-1H-naphtho[1,2-d]-imidazol-2-yl)carbamoyl]benzylphosphonate

Procedure

Using 2-amino-1-methyl-1H-naphtho[1,2-d]imidazole (commercially available) and 4-[(diethoxyphosphoryl)methyl]benzoyl chloride, the procedure of Example 1 was otherwise repeated to provide the objective compound.

Workup

  1. customto provide the objective compound

Sources & evidence

ORD record
ord-6c65b68d3d894869868980b348ac5e36
Source dataset
uspto-grants-1996_01
Patent number
US05480874

Reaction notes

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