4H-Indeno[2,1-d]thiazol-2-amine → diethyl 4-[N-(4H-indeno[2,1-d]thiazol-2yl)carbamoyl]benzylphosphonate

HRID 374424Notes

Reaction equation

HRID 374424 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[CH2:7][C:5]=2[N:6]=1.[CH2:14]([O:16][P:17]([CH2:22][C:23]1[CH:31]=[CH:30][C:26]([C:27](Cl)=[O:28])=[CH:25][CH:24]=1)([O:19][CH2:20][CH3:21])=[O:18])[CH3:15]>>[S:3]1[C:4]2[C:13]3[C:8]([CH2:7][C:5]=2[N:6]=[C:2]1[NH:1][C:27]([C:26]1[CH:30]=[CH:31][C:23]([CH2:22][P:17](=[O:18])([O:16][CH2:14][CH3:15])[O:19][CH2:20][CH3:21])=[CH:24][CH:25]=1)=[O:28])=[CH:9][CH:10]=[CH:11][CH:12]=3

Participants

3

Reactant 2

HCID 6047474H-Indeno[2,1-d]thiazol-2-amineHCID 104469734-[(Diethoxyphosphoryl)-methyl]benzoyl chloride

Product 1

HCID 18997041diethyl 4-[N-(4H-indeno[2,1-d]thiazol-2yl)carbamoyl]benzylphosphonate

Procedure

Using 2-amino-4H-indeno[2,1-d]thiazol and 4[(diethoxyphosphoryl)methyl]benzoyl chloride, the procedure of Example 1 was otherwise repeated to provide the objective compound.

Workup

  1. customto provide the objective compound

Sources & evidence

ORD record
ord-15b01dfc935444e29a38408f6f3914c0
Source dataset
uspto-grants-1996_01
Patent number
US05480874

Reaction notes

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