Sodium Hydroxide → HCID 15285850, compound

HRID 374426Notes

Reaction equation

HRID 374426 reaction equation
Br[C:2]1[C:3]([CH2:14][P:15]([OH:18])([OH:17])=[O:16])=[N:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]([OH:13])=[O:12])[N:10]=2)[CH:7]=1.[OH-].[Na+]>[Pd].O>[P:15]([CH2:14][C:3]1[CH:2]=[CH:7][N:6]2[CH:8]=[C:9]([C:11]([OH:13])=[O:12])[N:10]=[C:5]2[N:4]=1)([OH:17])([OH:18])=[O:16]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 15285849HCID 15285849, compound

Product 1

HCID 15285850HCID 15285850, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Procedure

6-Bromo-7-phosphonomethyl-imidazo[1,2-a]pyrimidine-2-carboxylic acid (18) (15 mg) was introduced in a 250 mL Parr bottle with 0.5N NaOH (1 mL), water (15 mL) and Pd on Carbon (5%, 20 mg). The bottle was evacuated, filled with hydrogen and shaken for one hour at room temperature. The product was purified by passing through a strongly basic ion-exchange column. The product 19 was eluted with 1N HCl.

Workup

  1. customThe bottle was evacuated
  2. additionfilled with hydrogen
  3. customThe product was purified
  4. washThe product 19 was eluted with 1N HCl

Sources & evidence

ORD record
ord-c37044d23f2747faad8475f2b5f3cc2a
Source dataset
uspto-grants-1996_01
Patent number
US05480876

Reaction notes

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