反应详情

温度

66 °C

6 ml of a 1N solution of sodium hydroxide are added to a solution of 2-isopropylamino-5-methoxycarbonylpyrimidine (1 g; 5.12 mmol) in 33 ml of methanol. The mixture is refluxed (66° C.) for two hours. A minimum of water is added in order to dissolve the precipitate which forms; the methanol is evaporated under reduced pressure. The remaining solution is acidified at 0° C. with 2N hydrochloric acid. The precipitate obtained is filtered, washed with water and then dried to give 850 mg (92%) of acid.

1. dissolutionto dissolve the precipitate which
2. customthe methanol is evaporated under reduced pressure
3. customis acidified at 0° C. with 2N hydrochloric acid
4. customThe precipitate obtained
5. filtrationis filtered
6. washwashed with water
7. customdried