Water → 2-(Isopropylamino)pyrimidine-5-carboxylic acid
Reaction equation
[OH-].[Na+].[CH:3]([NH:6][C:7]1[N:12]=[CH:11][C:10]([C:13]([O:15]C)=[O:14])=[CH:9][N:8]=1)([CH3:5])[CH3:4].O>CO>[CH:3]([NH:6][C:7]1[N:8]=[CH:9][C:10]([C:13]([OH:15])=[O:14])=[CH:11][N:12]=1)([CH3:5])[CH3:4]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 66 °C
Procedure
6 ml of a 1N solution of sodium hydroxide are added to a solution of 2-isopropylamino-5-methoxycarbonylpyrimidine (1 g; 5.12 mmol) in 33 ml of methanol. The mixture is refluxed (66° C.) for two hours. A minimum of water is added in order to dissolve the precipitate which forms; the methanol is evaporated under reduced pressure. The remaining solution is acidified at 0° C. with 2N hydrochloric acid. The precipitate obtained is filtered, washed with water and then dried to give 850 mg (92%) of acid.
Workup
- dissolutionto dissolve the precipitate which
- customthe methanol is evaporated under reduced pressure
- customis acidified at 0° C. with 2N hydrochloric acid
- customThe precipitate obtained
- filtrationis filtered
- washwashed with water
- customdried
Sources & evidence
- ORD record
- ord-cde52d22d4ca4915a52cdf74892bf0c5
- Source dataset
- uspto-grants-1996_01
- Patent number
- US05480884
Reaction notes
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