HCID 10498132, compound → HCID 9838237, compound

HRID 374448Notes

Reaction equation

HRID 374448 reaction equation
[CH2:1]([C:3]1[N:4]([CH2:17][CH2:18][O:19][C:20](=[O:25])[C:21]([CH3:24])([CH3:23])[CH3:22])[CH:5]=[CH:6][C:7](=[O:16])[C:8]=1[O:9]C(=O)C(C)(C)C)[CH3:2]>O>[CH2:1]([C:3]1[N:4]([CH2:17][CH2:18][O:19][C:20](=[O:25])[C:21]([CH3:24])([CH3:23])[CH3:22])[CH:5]=[CH:6][C:7](=[O:16])[C:8]=1[OH:9])[CH3:2]

Participants

3

Reactant 1

HCID 10498132HCID 10498132, compound

Product 1

HCID 9838237HCID 9838237, compoundYield 78.9%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-Ethyl-3-pivaloyloxy-1-(2-pivaloyloxyethyl)pyridin-4-one (0.5 g) was heated in distilled water (40 ml) at 70° C. for 3 hours. The water was removed by rotary evaporation and the residue dried under high vacuum. Recrystallization of the dry solid from ethyl acetate and petroleum ether (b.p. 40°-600° C.) gave the title compound (0.3 g, 69%) as colourless crystals with a melting point and infra-red and n.m.r. spectra as quoted in Example 2.

Workup

  1. customThe water was removed by rotary evaporation
  2. customthe residue dried under high vacuum
  3. customRecrystallization of the dry solid from ethyl acetate and petroleum ether (b.p. 40°-600° C.)

Sources & evidence

ORD record
ord-a39d37c8028346ab8151d5969bfff2ca
Source dataset
uspto-grants-1996_01
Patent number
US05480894

Reaction notes

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