HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl 4-Hydroxybenzoate → Benzoic acid, 4-[(2S)-oxiranylmethoxy]-, methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl 4-Hydroxybenzoate | HCID 7180 | — |
| Reactant | Methylparaben | HCID 7456 | — |
| Reactant | Epibromohydrin | HCID 18430 | — |
| Reactant | [(2S)-Oxiran-2-yl]methyl 2-methylbenzene-1-sulfonate | HCID 71369135 | — |
| Product | Benzoic acid, 4-[(2S)-oxiranylmethoxy]-, methyl ester | HCID 931644 | 90% |
Reaction Steps
The same procedure of Reference Example 4 was repeated except that methyl 4-hydroxybenzoate was used in lieu of benzyl 4-hydroxybenzoate, and (S)-(+)-glycidyl toluenesulfonate was used in lieu of epibromohydrin to give the title compound (yield 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05480899 |
| Source dataset | uspto-grants-1996_01 |
| ORD ID | ord-ec2c56d6fc0942b09e2a5ff02e8d7cc0 |
| Source note | uspto-grants-1996_01 |