反应详情

温度

50 °C

A 3.8 ml quantity of 8% sodium hydroxide aqueous solution was added to a methanol (20 ml) solution of 2.43 g of (4S, 5S)-(-)-3-(4-methoxyphenyl)-4-methyl-2-oxooxazolidin-5-ylmethyl p-nitrobenzoate obtained in Reference Example 8. The mixture was stirred at 50° C. for 20 minutes. The reaction mixture was concentrated under reduced pressure, and the obtained residue was extracted with ethyl acetate. The extract was washed with water, dried with magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure, and the residue was subjected to silica gel column chromatography and purified by hexane-ethyl acetate gradient elution to give 1.04 g of the title compound (yield 70%).

1. customobtained in Reference Example 8
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. extractionthe obtained residue was extracted with ethyl acetate
4. washThe extract was washed with water
5. dry with materialdried with magnesium sulfate
6. filtrationfiltered
7. concentrationThe filtrate was concentrated under reduced pressure
8. custompurified by hexane-ethyl acetate gradient elution