4-Chlorophenyl Isocyanate → HCID 53874791, compound

Participants

Reaction Steps

A 8.5 ml quantity of triethylamine was added dropwise to a dichloromethane (25 ml) solution of 2.5 g of 4-chlorophenyl isocyanate and 2.5 g of glycidol at 40° C., and the mixture was stirred at the same temperature for 20 hours. The reaction mixture was washed with 5% hydrochloric acid, dried with magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography and purified by dichloromethane-ethanol gradient elution to give 5.30 g of the title compound as an oil (yield 69%).

Provenance & Evidence