HCID 54210872, compound → HCID 53999981, compound

HRID 374501Notes

Reaction equation

HRID 374501 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:13][C@@:12]([CH2:15][O:16][C:17]3[CH:24]=[CH:23][C:20]([C:21]#N)=[CH:19][CH:18]=3)([CH3:14])[O:11][C:10]2=[O:25])=[CH:5][CH:4]=1.C[O:27]C1C=CC(N2[C@@H](C)[C@@H](COC3C=CC(C#N)=CC=3)OC2=O)=CC=1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:13][C@@:12]([CH2:15][O:16][C:17]3[CH:24]=[CH:23][C:20]([CH:21]=[O:27])=[CH:19][CH:18]=3)([CH3:14])[O:11][C:10]2=[O:25])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 54210872HCID 54210872, compoundHCID 67732715HCID 67732715, compound

Product 1

HCID 53999981HCID 53999981, compoundYield 85%

Procedure

The same procedure of Example 16 was repeated except that 4-[(R)-(-)-3-(4-methoxyphenyl)-5-methyl-2-oxooxazolidin-5-yl]methoxybenzonitrile obtained in Reference Example 15 was used in lieu of 4-[(4S, 5S)-(-)-3-(4-methoxyphenyl)-4-methyl-2-oxooxazolidin-5-yl]methoxybenzonitrile to give the title compound (compound 44) as an oil (yield 85%).

Workup

  1. customobtained in Reference Example 15

Sources & evidence

ORD record
ord-044add18d58a4d23bfb8cf839afdff74
Source dataset
uspto-grants-1996_01
Patent number
US05480899

Reaction notes

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