HCID 22405789, compound → HCID 18997181, compound

HRID 374503Notes

Reaction equation

HRID 374503 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:13][CH:12]([CH2:14][O:15][C:16]3[CH:23]=[CH:22][C:19]([CH:20]=[O:21])=[CH:18][CH:17]=3)[O:11][C:10]2=[O:24])=[CH:5][CH:4]=1)#N.C[O:26]C1C=CC(N2[C@@H](C)[C@@H](COC3C=CC(C#N)=CC=3)OC2=O)=CC=1>>[CH:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:13][CH:12]([CH2:14][O:15][C:16]3[CH:23]=[CH:22][C:19]([CH:20]=[O:21])=[CH:18][CH:17]=3)[O:11][C:10]2=[O:24])=[CH:5][CH:4]=1)=[O:26]

Participants

3

Reactant 2

HCID 22405789HCID 22405789, compound2×HCID 67732715HCID 67732715, compound

Product 1

HCID 18997181HCID 18997181, compoundYield 89%

Procedure

The same procedure of Example 16 was repeated except that 4-[3-(4-cyanophenyl)-2-oxooxazolidin-5-yl]methoxybenzaldehyde (compound 34) obtained in Example 2 was used in lieu of 4-[(4S, 5S)-(-)-3-(4-methoxyphenyl)-4-methyl-2-oxooxazolidin-5-yl]methoxybenzonitrile to give the title compound (compound 173) in a yield of 89%.

Workup

  1. customobtained in Example 2

Sources & evidence

ORD record
ord-3fa8860afcf041b082db5f0e05f2c396
Source dataset
uspto-grants-1996_01
Patent number
US05480899

Reaction notes

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