Hydrochloric Acid → HCID 54462173, compound

Participants

Reaction Steps

Lithium aluminum hydride (59 mg) was added to a tetrahydrofuran (15 ml) solution of 750 mg of methyl 3-{4-[3-(4-chlorophenyl)-2-oxooxazolidin-5-yl]methoxy-phenyl}propionate (compound 191) obtained in Example 32. The mixture was stirred with ice-cooling for 40 minutes in a stream of nitrogen. To the reaction mixture was added 5% hydrochloric acid, and the mixture was extracted with ethyl acetate. The extract was washed with an aqueous solution of sodium chloride, dried with magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography and purified by hexane-ethyl acetate gradient elution to give 498 mg of the title compound (compound 194) in a yield of 71%.

Provenance & Evidence